Nature gives us strength and ways....






Melatonin is a hormone found in all living creatures, produced by pinealocytes in the pineal gland (located in the brain).

It was discovered by Lerner in 1958.

Normally, the production of melatonin by the pineal gland is inhibited by light and permitted by darkness. For this reason melatonin has been called "the hormone of darkness." The secretion of melatonin peaks in the middle of the night, and gradually falls during the second half of the night.

Some studies are not considering melatonin as a hormone because it is produced by different organs during the day, and because dose of some mg per day do not cause side effects (such as other hormones).

Melatonin is practically nontoxic and exhibits almost no short-term side effects. However, melatonin derived from animal sources may be contaminated with viral material; synthetic melatonin may be taken to avoid this risk. No studies have been conducted yet to determine whether there are any long-term side effects.

Even though it is seen as a relatively safe, benign drug, especially to herbal enthusiasts, it can cause some unwanted side effects, especially at high doses. But it is sold in supermarkets and herbalist's shop, without medical prescription. Some people think it is a nourishment, not a medicine, but you can have some side effects, except you doctor suggest about dose and time of consumption.

First use of melatonin as therapy was on 1969 with the trials of dr. Luigi Di Bella that guessed a potential therapy (it is a current debate about use of melatonin in his treatments).

Dosages are designed to raise melatonin levels for several hours to enhance quality of sleep, but some studies suggest that smaller doses are just as effective at improving sleep quality, and it appears to have some use against circadian rhythm sleep disorders, such as jet lag. It seems melatonin synchronizes biological clock. A recent issue of British Medical Journal has considered 10 random trials where melatonin has been compared with placebo in long distances travelers. 8 of them shown melatonin effective in jet-lag effects.

2 to 5 mg of melatonin is enough before sleeping the day after the flight and in the next 2/4 days, to settle the rate on the new time zone.

The issue confirms that the melatonin is not registered as a pharmacy in the EU.

This is because of the law on patents (EU countries, also in Italy) where natural substances are not patentable.

The prescription is not forbidden, but deprives the market of this product and makes its finding hard.